The influence of sleep on the visual arts is reviewed with examples from the greatest artists including Van Gogh (shown here), Sargent, Carravagio, Botticelli, Morisot, Steen and many others.
Chapter 2. History of Sleep Medicine: Author; Meir Kryger
From Hippocrates to Dickens to the discovery of sleep apnea (this image is from a paper by Annie Spitz in the 1930s, the first known photo of an apnea patient) to the invention of CPAP to the discovery of orexin and the genes for narcolepsy.
Chapter 3. Biology of Sleep ; Authors; experts from leading medical centers in the USA, Australia, and Europe
Topics include Sleep Mechanisms, Circadian Physiology, Physiologic Regulation, Immune Function and Cytokines, Control of Breathing (this figure brainstem centers that control breathing), Cardiovascular Regulation, Regulation of Feeding, Endocrine Physiology.
Chapter 4. Normal Sleep: Authors; Jerome Siegel, Alon Avidan
This chapter reviews normal sleep in animals and humans. It includes definitions and normal values and gives examples using the new AASM definitions.
Chapter 5. Sleep Restriction: Authors; Andrea Spaeth, Takashi Abe, Jason Schneiderman, and avid Dinges
This chapter reviews the many deleterious effects of sleep restrictions in humans.
Chapter 6. Pharmacology: Author; Wally Mendelson, Andy Krystal
This chapter reviews the medications used in sleep medicine in cluding hypnotics and wake promoting agents (shown here).
Chapter 7. Dreaming: Authors; Erin Walmsley, Bob Stickgold
This chapter reviews the physiology and pathophysiology of dreaming
Chapter 8. Impact, Presentation, Diagnosis: Authors; Goldstein, Swanson, Arnedt, Chervin
This chapter reviews the impact of sleep disorders on society, how patients present, and how they are diagnosed.
Chapter 9. Cicadian Rhythm Sleep Disorders: Authors; Kathryn Reid, Phyllis Zee
This chapter reviews the circadian rhythm sleep disorders (jet lag shown here) and how to diagnose them and treat them
Chapter 10. Insomnia: Authors; Jack Edinger, Meir Kryger and Thomas Roth
This chapter reviews the pathophysiology (including newer theories of hyperarousal, evidence shown here), diagnosis and treatment of primary and comorbid insommnia.
Chapter 11. Neurological Disorders: Authors; Chad Ruoff, Emmanuel Mignot, Richard Allen, Rachel Salas, Charlene Gamaldo, Marco Zucconi, Michelangelo Maestri, Raman Malhotra and Alon Avidan
This chapter reviews narcolepsy, idiopathic hypersomnia, restless legs syndrome, epilepsy (shown here), Parkinson's disease and REM sleep behavior disorder.
Chapter 12. Parasomnias: Authors; Michael Howell and Carlo Schenck
This chapter reviews the REM (REM behavior disorders) and NREM parasomnias (sleep walking, night terrors, bruxism) and seizures. This is an example of the development of sleep terrors.
Chapter 13. Sleep Breathing Disorders: Authors; Don Hayes, Mark Splaingard, Stephen Sheldon, Christine Won and Meir Kryger,
This chapter reviews the clinical features, physical examination, diagnostic methods used to diagnose and treat the various types of sleep apnea and the overlap syndromes in adults and children. Shown here are enlarged tonsils in an apnea patient.
Chapter 14. Cardiovascular Disease: Author; Shahrokh Javeheri, Lauren Tobias and Klar Yaggi
This chapter reviews the the interaction between cardiovascular disease and sleep and present the sleep problems seen in heart failure (Hunter-Cheyne-Stokes) and stroke (shown here) and how they are diagnosed and treated.
Chapter 15. Medical Disorders: Authors; Charles George, William Orr, Nuna Canales, Richard Berry and Meir Kryger
This chapter reviews the sleep disorders in thyroid disease (example above is the eye signs in a patient with burnt out Graves disease with sleep apnea), acromegaly, diabetes mellitus, gastrointestinal and renal diseases.
Chapter 16. Women Health: Author; Kathryn Lee, Kin Yuen, Carol Landis
This chapter reviews the disorders associated with mensutruation, pregnancy, postpartum, menopause and fibromyalgia. This image represent a polycystic ovary; many woman with this condition have sleep apnea.
Chapter 17. Psychiatric Disorders: Authors; Catherine McCall, Colin Shapiro and W. Vaughn McCall
This chapter reviews the interaction between psychiatric disease and sleep.
Chapter 18. Diagnostic Methods: Authors; Max Hirshkowitz, Amir Sharafkhanel
This chapter reviews the new AASM scoring rules for sleep staging and respiratory events. Also included are rules for scoring cyclic alternating patterns. Technical specifications are provides. Home sleep testing (shown here) is reviewed.
Chapter 19. Gallery of Polysomnophic Recordings: Authors; Max Hirshkowitz and Meir Kryger
This chapter contains 125 PSG fragments covering sleep breathing disorders, neurological disorders, cardiovascular disease (Cheyne Stokes breathing in a 9 year old child with mitral valve disease caused by rheumatic fever is shown at the top and OSA below), and artifacts.
Chapter 20. Gallery of Patient Interviews
This chapter is a catalog of many video interviews with patients with sleep breathing disorders, neurological disorders, cardiovascular and neuromuscular diseases. Also included (example shown) is a CPAP mask fitting. The videos are on the website.
Chapter 21. Gallery of Sleep Lab Videos
This chapter is a catalog of dozens of video obtained in the sleep laboratory that can be seen on the website. It includes the broad spectrum of patients seen in a sleep clinic. This is a patient with obesity hypoventilation syndrome and right sided heart failure, with massive peripheral edema.